Esther Formula Glutathione Direct Film 5X (For Brightening)

24 reviews
$51.10 $73.00



  • Recommended for: Individuals looking for a brightening inner health product.
  • Nutritional Notes: It is not vegan or halal certified.
  • 1 box consists of 30 film patches for consumption (1 film = 325mg). 
  • Consult your physician or healthcare professional before taking the product. If abnormalities occur, discontinue use and consult a doctor.
  • Note: There is no taste difference between Glutathione 5X and 3X.
  • Volume: 60g

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Esther Formula's Best-seller Product  — Over 150 million films (50 million boxes) sold in Korea!

No.1 Most Trusted Health Supplement Brand in Korea, consumed by every household — Esther Formula by renowned preventive doctor, Dr. Yeo Esther is here!

Introducing Korea's first mucoadhesive glutathione film by Esther Formula and their bestseller product, now back stronger with its upgraded version — Esther Formula Glutathione Direct Film 5X.

It is packed with 5 times stronger Glutathione network formed by special blending ratio of 5 ingredients to aid in brightening skin effectively.

Carefully selected glutathione from the Netherlands with a highest purity of over 75%. This version is the upgraded version of their original Glutathione Film with the maximum content and highest purity.

  • 75% Highest Purity
  • Highest, Maximum Content!
  • 5X stronger!

Mucoadhesive method = Better absorption! 


Glutathione is the most abundant and a powerful antioxidant found in our cells to protect the body from damage by free radicals, peroxides, and heavy metals. It is also essential for the immune system’s proper functioning and is vital in building and repairing tissue. 

While this fascinating compound has a wealth of medical uses, it is also an exceptional skin care ingredient (often called the wonder drug for hyperpigmentation) and now, even as an inner health item

Though naturally created in our bodies by the liver, glutathione’s production naturally declines as we age, similar to that of collagen. This decline in production is believed to contribute to the onset of visible aging, also the very reason why we need glutathione in our daily to provide the brightening effects it has for our skin. 


 Skin Brightening 

It reduces oxidative stress in the body to improve your overall complexion.

 Helps with skin wrinkles and skin elasticity 

It helps reduce wrinkles and increase skin elasticity by working on the skin pigment production by inhibiting tyrosinase, an enzyme involved in making melanin.


As it is a natural detoxifier, it improves the health of the body's cells to reverse ageing by removing free radicals through oxidation-reduction reactions and maintains antioxidants in the body.


Glutathione is not an ingredient for dietary supplements recognised by the Ministry of Food and Drug Safety, so there is no official intake guide. The general capsule or tablet types of glutathione products is effective when ingested at 100-200 mg.

According to the results of the SCI-level thesis, about 10% of above general products are moved to blood vessels and to various parts of the body, where they are absorbed into the liver and organs.

There is a result that even though these general products are absorbed by the body by 55% after 10 minutes and up to 70% after 30 minutes, they can still be lost while moving through the digestive system, so the absorption through blood vessels is important!

It has been confirmed that for the film-type product, more than 70% of glutathione moves through blood vessels, and our Glutathione 5X product is 80mg, so it is effective even at the corresponding intake. It is also possible to increase the intake up to 3 times depending on the skin condition or the condition of the consumer!

It has been confirmed that for the film-type product, more than 70-80% of glutathione moves through blood vessels. For our Glutathione 5X product, it also means 70-80mg (this can vary slightly according to the harvest period of glutathione yeast extract) out of 100mg is absorbed. It is also possible to increase the intake up to 3 times depending on the skin condition or the condition of the consumer!


  • Take 1 or 2 film once a day. Stick film at the roof or inner side of cheek in the mouth.
  • Step 1: After opening the oral dissolving film, you have to pick it up with your fingers and attach it to your oral mucous membrane so remember to wash your hands first.
  • Step 2: Open the film pouch. Gently open the film pouch from the opening side.
  • Step 3: Attach the oral dissolving film to the roof of your mouth.

*Kindly be advised for shipping food product overseas, please check and be advised by the local regulatory authorities before carting out.

Please refer to our shipping policy on wellness products for complete info: Shipping policy

Individuals looking for a brightening inner health product.

30.77% (L-Glutathione 75%, Netherlands), Fulluran, Vitamin C, Lemon Juice Powder [Dextrin, Lemon Juice ((Lemon 100% ; USA), Gum Arabic, Citric Acid, Mixed Preparation (Alcohol, Purified Water, Natural Flavour)], Hydroxypropylmethylcellulose, Enzyme-Treated Stevia, Milk Thistle Extract :Powder (USA), Beta-Cyclodextrin, Glycerin, Natural Flavor (Natural Lemon Flavour), Other Edible Oils and Fats, Vitamin E, Gardenia Yellow

2 July 2026

Precautions for Storage: Store in a cool and dry place, avoiding high temperatures, high humidity and direct sunlight.

1. Do not recycle for other purposes. Keep out of the reach of children.
2. Please consume it as soon as you open it.
3. If you have a medical condition or take any medication, consult a doctor prior to usage.
4. If you have any allergies, an overreaction may occur depending on each individual’s condition, so please check the raw materials before consuming it.
5. Consult your physician or healthcare professional before taking the product. If abnormalities occur, discontinue use and consult a doctor.
6. Please be careful when opening the product as you may get injured by the packaging materials.
7. This product is manufactured in facilities that use eggs (poultry), buckwheat, peanuts, soybean, wheat, mackerel, crab, shrimp, pork, peach, tomato, sulphuric acid, walnuts, chicken, beef, squid, shellfish (including oysters, abalone, mussels), and fish.

1. How should I take it?
Attach it to the roof of your mouth whenever and wherever you want.

2. How many times should I take it?
Attach 1 film a day to the roof of your mouth.
It’s okay to take 2 films twice a day in a row or at intervals.

3. Can 5x and 3x be taken concurrently?
Yes, you can!

4. Can vegetarians or vegans consume Glutathione 5X?
There is a small amount of milk in the product. As there are varied types of vegetarian diets, we recommend individuals to check the ingredient list before purchase or consumption.

5. Can I take more than the recommended amount?
Yes, you can. Esther Formula Glutathione Direct Film is categorised as food (other processed product) and the daily intake is not set. If you want intensive management, you can take as much as you need.

According to the clinical results, there are many results of taking 500-1000mg/day of glutathione is recommended for oral intake. However, Glutathione Direct product is a film formulation that can be absorbed through the mucous membrane, and the vascular mobility of glutathione is 8 times higher than that of oral intake.

Therefore, taking 1 sheet a day is sufficient, but if you want to increase intake for maximum effect, we recommend taking up to 3-4 sheets a day. In addition, even if you consume more than 4 sheets, excessive intake does not cause any side effects in the body.

6. Is it okay to take it for a long time?
Yes, it’s okay. Esther Formula Glutathione Direct is categorised as food (other processed product) and unless you have a specific constitution or are sensitive to external immune reactions, long-term intake does not cause any specific problems in the human body.

7. Is it safe for pregnant or lactating women?
Pregnant and lactating women can also take it. However, since it is a sensitive period, please consult with your doctor before taking it.

8. How long do I have to take this product for results to show?
The intake period during which you can feel the effect varies from person to person, but it is usually 1-3 months later.

9. Is it suitable for all age groups?
Yes it is. However, we do not recommend 1-2 years old children who doesn't have full control over their bodies to consume as it might get stuck in the throat.

10. How should we bring this product when travelling overseas?
It is a product that can be stored at room temperature and is packaged individually, making it easy to carry around when traveling.

11. Should this product be taken before or after food?
It can be taken before or after a meal, so please take it at a time when you can consume it consistently.

12. Is there any animal derived ingredients since it is not vegan?
The product does not contain animal ingredients. However, it is manufactured in the same facility as products using pine nuts, eggs (poultry), buckwheat, peanuts, soybeans, wheat, mackerel, crab, shrimp, pork, peaches, tomatoes, sulfite, walnuts, chicken, beef, squid, shellfish (including oysters, abalone, mussels). They should check if this is okay for them before consuming.

13. Can we take up to 4 daily? Or taking up to 4 should only be occasionally? (Since one of the images show can take up to 4)
• Glutathione is a component that exists in the human body and the amount of daily intake is not specified. Depending on the situation of the consumer, it is possible to consume 4 or more sheets per day.
• However, it contains 50mg of glutathione per sheet and clinical results show that more than 80% of it is transferred to blood vessels when absorbed through mucous membranes (roof of mouth), so taking 1 sheet per day is actually enough.
• Therefore, take 1 sheet daily according to the recommended range, but you can increase the intake on some days when you want to take a little more depending on the condition of that days.

14. Should we also advise to avoid drinking alcoholic beverages while taking this product?
It can be taken before drinking, and if you have been drinking, it is recommended to take it an hour later. However, it is safe to consume immediately after drinking as it does not cause side effects in the body.

15. Can customers drink hot or acidic beverages before or after taking this product?
• Hot or acidic beverages may be consumed prior to taking Glutathione Direct.
• In addition, if the mucous membrane in the mouth is dry before taking Glutathione Direct, it will not adhere well, so if you take it after drinking, the mucous membrane will remain moist and adhere easily.

16. If we want to take 2 films, can we take both at the same time or should take 1 after another?
You can either attach the two films at the same time or take them one by one, so please take it in a way that is convenient for you.

17. This is not halal-certified but can it be consumed by Muslims?
The product is manufactured in the same facility as products using pine nuts, eggs (poultry), buckwheat, peanuts, soybeans, wheat, mackerel, crab, shrimp, pork, peaches, tomatoes, sulfite, walnuts, chicken, beef, squid, shellfish (including oysters, abalone, mussels).

Please kindly check if this is okay before consuming.

18. If we are taking collagen, probiotics, Gongmi, Omega, when should we consume this? Any interactions with Glutathione?
• There are no ingredients that are limited to intake with the same time as glutathione.
• Therefore, it is also possible to consume them all at the same time. However, since our Glutathione Direct product is a product that is attached to the roof of the mouth for absorption through the mucous membrane of the mouth, please take it by attaching it to the mucous membrane of the mouth by itself after taking all other supplements.
• Glutathione is a powerful antioxidant component in the body, and is more effective when simultaneously consumed with vitamins C, E, A, beta-carotene, selenium, copper, and zinc, which are involved in antioxidant metabolism. Therefore, Glutathione Direct product contains vitamin C, vitamin E and milk milk thistle (silymarin) as Dr. Esther's own formula.

19. mention that taking Glutathione long-term has been linked to lower zinc levels. Is there a need to take a break or can consume continuously?
Even if you take zinc preparations, you can take glutathione every day without a break.

Zinc and glutathione are representative antioxidants and act complementary to each other during antioxidant metabolism in the body. In other words, zinc used in antioxidant metabolism is oxidised, but glutathione converts it back to reduced zinc to be used again in antioxidant metabolism.

So even if you take zinc, you can continue to take glutathione daily.

20. How long does it take for the film to dissolve in the mouth? Can one eat/drink when the film is not fully dissolved?
Since the amount of salivary secretion varies from person to person, the dissolution time may vary from person to person. We inform you that the approximate time is 5-10 minutes, and if Yeo Esther Glutathione Direct Film is attached to the mucous membrane, most of the glutathione will be moved to the mucous membrane by simple diffusion.

To provide detail information, the absorption of glutathione occurs by simple diffusion due to concentration differences. In other words, if the film is attached to the mucous membrane, glutathione moves to the mucous membrane due to simple diffusion into the mucous membrane with a low concentration, since glutathione is herpes at a high concentration outside the mucous membrane where the film is dissolved by saliva.

Therefore, if the glutathione film adheres well only to the mucous membrane, saliva comes out or the tongue touches it. If you have other food in your mouth, the film is easy to fall off the mucous membrane, so it is recommended to consume it by product itself.

21. How does working on the skin pigment production help to reduce wrinkles and improve skin elasticity?
Glutathione functions as a powerful antioxidant within our body. Anti-oxidation means to prevent cellular oxidation caused by free radicals in the body, and is closely related to anti-aging.

Accordingly, in a paper published in cosmetic and investigational dermatology in 2017, a clinical study was conducted to evaluate the effects of oral intake of reduced and oxidised glutathione on skin aging indicators, and the results were reported as follows. "A significant reduction in wrinkles was observed in the glutathione intake group compared to the placebo intake group, and a tendency to increase skin elasticity was observed in both the reduced and oxidised glutathione intake groups."

In addition, while reporting the results of a clinical study to evaluate the effect of oral intake of glutathione on skin aging indicators, the study's conclusions are presented as follows. "To summarise paper, we show that oral intake of reduced and oxidised glutathione has various benefits for skin properties and can perform an anti-aging function, at least in middle-aged women."

22. Can this help to reduce hyperpigmentation concerns such as melasma?
Glutathione Direct product is not a medicine, so it is not an immediate means of treating melasma. Everyone knows that the factor that determines the colour of our skin is melanin pigment. Reports that glutathione affects the melanin pigment index have been continuously accumulated in the academic world. That said, oral antioxidants like glutathione can reduce melanogenesis by inhibiting free radicals.

Based on these preceding studies, the results of a randomized, double-blind clinical study were published in The Journal of dermatological treatment in 2012 to examine the effect of oral glutathione intake on the improvement of melanin index in healthy adults. "All 60 subjects completed the study, and the melanin index of the glutathione intake group continuously decreased in all six body parts observed for 4 weeks of intake."

To be more detail, the production of melanin, which is the cause of melasma, begins when L-tyrosine is converted into dopaquinone by the enzyme tyrosinase. Glutathione inhibits tyrosinase in three ways. Direct inhibition through copper chelation, indirect inhibition through antioxidant effects, and inhibition of migration to the premelanosome. Thus, glutathione changes the way melanin is produced from eumelanin to pheomelanin through the reaction between dopaquinone and thiol groups through the formation of sulfhydryl group-dopa conjugates.

23. Can those taking tranexamic acid tablets for skin whitening take this?
Yes, Tranexamic acid and glutathione have different melanin inhibition mechanisms, so intake is not restricted. Glutathione is a food as well as an antioxidant component present in the body.

In Korea, there is a guide to consume after consulting with a dermatologist, so please refer to it.

24. Does it help with tanned skin?
When tanning the skin to achieve a deep tan as a means to enhance one's beauty, either by exposing the skin to UV radiation outdoors or artificially using UV machines, it's important to note that while you may attain the desired skin tone, you may also accelerate skin aging simultaneously. Glutathione, a powerful antioxidant, helps protect skin cells from oxidative stress, which is a leading cause of internal aging. Therefore, if you engage in tanning, it is advisable to consider taking glutathione supplements as an essential part of concurrent skincare for your skin's health.

25. Does the type of food we consume daily affect the efficiency of Glutathione?
Since glutathione is an antioxidant component, it is recommended to consume vegetables and fruits that contain a lot of phytochemicals.

On the other hand, there are no specific food that affect the absorption rate of glutathione.

For more reference: Please refer to

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Filter Reviews:
20 Jun 2024
Francine L.
Singapore Singapore

Esther Formula Glutathione Direct Film 5X

This products works. It has been controlling my melasma and for 4 months now, I need not go on my tranexamic acid medication. I have been taking 2 films each day for 4 months now. It’s a good deal when there’s a promotion.

31 May 2024
Shona T.
Singapore Singapore

Glutathione film

Multiple purchases. Great product

16 May 2024
Francine L.
Singapore Singapore

Esther Formula Glutathione Direct Film 5X

I am happy with the product.. It seems to be helping with lightening my melasma . I take 2 films each day and have been doing it for the past 3 months.

14 May 2024
Beatrice G.
Singapore Singapore

Esther Formula Brewer's Yeast Plus

I did not see any improvement :(

14 May 2024
Francine L.
Singapore Singapore

Esther Formula Glutathione Direct Film 5X

I have been using the film for 3 or 4 months now. I take 2 films each morning as to control my melasma. Seems to be effective as in, I don’t see my melasma getting darker. I will continue to take it and the promotion price is really a good deal.

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